Th2类细胞因子水平的影响.doc

胸腺肽α1对慢性乙型肝炎患者Th1/Th2类细胞因子水平的影响
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作者:何和章,吴,王光余
【摘要】目的:观察胸腺肽α1联合拉米夫定对慢性乙型肝炎(CHB)患者Th1 /Th2类细胞因子表达的影响。方法:将慢性乙型肝炎患者48例,分为治疗组24例和对照组24例,采用双抗体夹心酶联免疫吸附法检测两组Th1类细胞因子γ干扰素(IFNγ)和Th2类细胞因子白介素4(IL 4) , HBVDNA水平并比较治疗前、后变化。结果: 治疗组和对照组在治疗后6个月乏力、纳差、肝区不适等症状、体征均有所改善,但治疗组改善情况优于对照组,总有效率(%,23/24)明显高于对照组(%,18/24)(P<)。对照组治疗前后各指标差异均无统计学意义(P>);治疗组治疗后IL4,HBVDNA水平较治疗前及对照组治疗后明显降低(P<),IFNγ水平明显升高(P<)。结论: 胸腺肽α1能明显提高慢性乙型肝炎患者的Th1类细胞因子中IFNγ表达水平, 改善患者Th1 /Th2细胞功能失衡状态, 有利于病毒的清除。
【关键词】胸腺肽α1;慢性乙型肝炎;Th1/Th2类细胞因子;
γ干扰素;白介素4;酶联免疫吸附法
[ABSTRACT] Objective: To observe the effect of Thymic Peptide bine with Lamivudine on levels of Th1/Th2like cytokine in chronic hepatitis type B patients. Methods: A total of 48 cases with chronic hepatitis type B were divided into the treatment group and the control group by half. The levels of Th1like cytokine (IFNγ), Th2like cytokine (IL4) and HBVDNA were tested by quantitative enzymelinked sandwich immunoassay method. Meanwhile, the changes pared before and after the treatment. Results: Symptoms and signs in both group changed after treatment in 6 months including lack of power,poor appetite and liver was fortable. But the condition of treatment group was better than control gourp. The total effective rate in treatment group (%,23/24) was higher then control group (%,18/24) (P<)