乌体林斯预防儿童激素敏感型肾病综合征复发的效果.doc

乌体林斯预防儿童激素敏感型肾病综合征复发的效果
【摘要】目的观察乌体林斯(草分支杆菌注射液)预防糖皮质激素(激素)敏感型肾病综合征(SSNS)复发的疗效并探讨其机制。方法选择52例SSNS为研究对象,随机分为观察组(27例)和对照组(25例)。两组均采用国内通用的标准中长程激素方案治疗,观察组在尿蛋白转阴后加用乌体林斯肌肉注射每周1次,共12周。观察两组治疗过程及疗程结束1年内复发情况,两组频复发例数、不频复发例数及无复发例数的差异。另外,观察组15例和对照组13病儿进行了辅助性T淋巴细胞亚群(Th1、Th2)动态检测。结果观察组在维持治疗过程中、疗程结束后1年内复发平均人次均显著低于对照组(t=、,P<),频复发例数和非频复发例数均明显少于对照组(χ2=、,P<),而无复发例数则明显高于对照组(χ2=,P<)。两组病儿激素治疗前Th1、Th2细胞百分率和Th1/Th2比值均无显著性差异(P均>)。观察组经乌体林斯治疗后Th1细胞百分率和Th1/Th2比值均明显高于对照组,差异有显著性(t=、,P<),而Th2细胞百分率虽低于对照组,但差异无显著性(P>)。结论乌体林斯预防SSNS复发疗效确切,其机制与调节Th1/Th2功能平衡,促进SSNS免疫异常的恢复和提高机体抗感染能力等有关。
【关键词】肾病综合征v 复发 T淋巴细胞辅助诱导草分支杆菌治疗结果儿童
[ABSTRACT] Objective To observe the effects of Wutilinsi injection (Mycobacterium phlei injection) on antirelapse in steroidsensitive nephrotic syndrome (SSNS) and investigate its mechanism. Methods Fiftytwo children with SSNS were enrolled in this study, randomized into observation group (27 cases) and control group (25). They were treated according to the standard for mediumandlongterm steroid therapy plan generally applied domestically. Wutilinsi injection was given to those in observation group, once a week for 12 weeks, urine protein was negative. The relapse during the treatment and within one year after that was investigated. A dynamic detection for adjuvanticity Thelper lymphocyte subsets was done in 15 cases in