旋光度法测定盐酸麻黄碱滴鼻液的含量.doc

旋光度法测定盐酸麻黄碱滴鼻液的含量
【摘要】目的用旋光度法替代酸碱滴定法测定盐酸麻黄碱滴鼻液的含量。方法分别用旋光度法与酸碱滴定法测定盐酸麻黄碱滴鼻液的含量,并将其结果进行比较。%~%(g/ml)浓度之间线性关系良好(r=),平均回收率(n = 9)%,RSD =%;与酸碱滴定法所测得样品结果经统计学检验,差异无显著性。结论旋光度法简便、快速、准确,可用于盐酸麻黄碱滴鼻液的含量测定。

【关键词】盐酸麻黄碱滴鼻液;旋光度法;含量测定

Determination of ephedrine hydrochloride nasal drops by polarimetry

DING Hui-ping,HUANG Ping,PAN Yong,et al. Tumor Hospital of Hunan Province,Changsha 410006,China

【Abstract】 Objective To determinate the content of ephedrine hydrochloride nasal drops by polarimetry instead of acid-base titrations. Methods Ephedrine hydrochloride nasal drops was quantified by polarimetry and acid-base titrations. The data were analyzed by t- The assay of polar
imetry was linear over the range of %~%(g/ml)(r=). The average recovery was %(n=9) with RSD =%. The difference of the data obtained by polarimetry and acid-base titrations was not significant. Two methods were statistically equivalent for the determination of ephedrine hydrochloride nasal The polarimetry is easy, rapid and accurate for the determination of the content of ephedrine hydrochloride, and can be used as an alternative method of acid-base titrations to determinate ephedrine hydrochloride nasal drops.

【Key words】 ephedrine hydrochloride nasal drops;polarimetry;content determination

《中国医院制剂规范》第2版[1]收载的“盐酸