L-氨基酸席夫碱的无溶剂法合成及其结构表征有机化学.pdf.pdf

2011 年第 31 卷有机化学 Vol. 31, 2011 第 6 期, 832 ~835 Chinese Journal anic Chemistry No. 6, 832 ~ 835 * E-mail: youjunjun@ Received November 12, 2010; revised January 5, 2011; accepted January 24, 2011. 国家自然科学基金(No. 20272011) 资助项目. ·研究论文· L - 氨基酸席夫碱的无溶剂法合成及其结构表征由君王鑫刘波* 陈艳琼( 哈尔滨理工大学化学与环境工程学院黑龙江省高校绿色化工技术重点实验室哈尔滨 150040) 摘要报道了一种新颖的 L - 氨基酸席夫碱的制备方法. L - 丙氨酸( L -ala), L - 丝氨酸( L -ser), L - 缬氨酸( L -val), L -亮氨酸( L -leu), L - 异亮氨酸( L -Ile), L - 苯甘氨酸( L -phg), L - 苯丙氨酸( L -phe) 七种氨基酸与水杨醛或 2- 羟基-1- 萘醛在氢氧化钾存在下, 室温研磨得到相应的氨基酸席夫碱. 所得产品经核磁共振氢谱、碳谱、红外光谱、质谱、元素分析等检测手段进行结构表征. 实验结果表明, 该反应室温只需 10 min 即可进行完全, 产品纯度好, 收率大于 90%. 关键词无溶剂合成; L - 氨基酸; 水杨醛; 2- 羟基-1- 萘醛; 席夫碱 Solvent-Free Synthesis and Characterization of L -Amino Acids Schiff Bases You, Jun Wang, Xin Liu, Bo * Chen, Yanqiong ( Key Laboratory of Green Chemical Technology , College of Heilongjiang Province , School of Chemical and Environmental Engineering , Harbin University of Science and Technology , Harbin 150040 ) Abstract A new solvent-free method was described for the synthesis of L -amino acids Schiff bases by the reactions of L -alanine ( L -ala), L -serine ( L -ser), L -valine ( L -val), L -leucine ( L -leu), L -isoleucine ( L -Ile), L -phenylglycine ( L -phg), L -phenylalanine ( L -phe) with salicylaldehyde or 2-hydroxy-1-naphthaldehyde, re- spectively, in the present of KOH at r