Heck反应及金属催化偶联反应.ppt.ppt

Heck 反应南京航空航天大学仿生结构与材料防护研究所汝杰过渡金属催化的交叉偶联反应 Transition Metal Catalyzed Cross Coupling A A B hemist The formation of carbon – carbon bonds is a fundamental reaction anic synthesis the efficiency of which has anic chemists for a long time ago. Aryl – aryl bond formation has been known for more than a century and was one of the first reactions involving a transition Modern synthetic chemistry is also sustained by the use of transition-metal catalysts as powerful tools for carbon – carbon bond-forming Among these, carbon – carbon coupling reactions through the activation of carbon – hydrogen bonds,3 as well as addition reactions,4 have experienced an increasing interest in the preparation of molecules, the access to which is not so straightforward using other methodologies. On the other hand , the transition-metal catalysed carbon – carbon bond formation developed in the 1970s represented a milestone in anic chemistry that allowed the cross coupling of substrates in ways that would have previously been thought impossible 2010 Nobel prize 瑞典皇家科学院说,这三名科学家因在有机合成领域中钯催化交叉偶联反应方面的卓越研究获奖。这一成果广泛应用于制药、电子工业和先进材料等领域,可以使人类造出复杂的有机分子。 赫克,79 岁,美国特拉华大学名誉教授;根岸荣一,75 岁,美国普渡大学化学教授;铃木彰,80 岁,日本札幌北海道大学教授。 Glaser (Hay) Coupling Suzuki Coupling [Pd]or[Ni]Base R 1X 2R B(OH) 2 + 1RR 2 R 1 H XR 2+ R 1 R 2 plex,CuI Amine Sonogashira Reaction Amination Reaction