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四妙勇安汤 异病同治 动脉粥样硬化与血栓闭塞性脉管炎机制研究.pdf


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四妙勇安汤_异病同治_动脉粥样硬化与血栓闭塞性脉管炎机制研究世界中医药 2021 年 9 月第 16 卷第 18 期 ·2663·
四妙勇安汤“异病同治”动脉粥样硬化
g atherosclerosis and thromboangiitis obliterans by bioinformatic analysis.Methods:The active compounds and corresponding tar-
gets of 4 traditional Chinese medicines from SMYA Decoction were obtained by database mining and retrieval.The associated targets
of AS and TAO were screened by GeneCards,CTD and NCBI database.Venny 2.1 was used to obtain the common targets of the two
diseases of drug action.The PPI network of common target proteins was constructed through STRING database.Cytoscape 3.7.2
software was used to construct drug-active compound-common target-disease global regulatory network diagrams.The GO classified
enrichment analysis and KEGG pathway enrichment analysis were performed using Bioconductor platform.Results:The common
targets of SMYA Decoction in As and Tao were mainly 47,including VEGFA,IL6,Jun,TNF,FOS,MAPK8,MMP9,IL10,ICAM1,
etc.A total of 9 active components,mainly flavonoids and sterols,were screened out.These targets were enriched by KEGG pathway
and participate in the regulation of multiple pathways such as AGE-RAGE signaling pathway in diabetic complications,TNF signa-
ling pathway,fluid shear stress and atherosclerosis,human cytomegalovirus infection,apoptosis,T cell receptor signaling p

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