异基因骨髓间质干细胞移植医治系统性红斑狼疮.docx

异基因骨髓间质干细胞移植医治红斑狼疮11例临床分析
【摘要】目的探讨异基因骨髓间质干细胞（MSC）移植医治难治性系统性红斑狼疮 （SLE）的疗效及安全性。方式 血缘相关供者骨髓中分离培育MSC移植医治11例SLE患 者，移植前予环磷酰胺（ weight introvenously. Before MSCT, all patient were given cyclophosphamide(CTX) 400~1800mg divided by two to three times. The clinical manifestations and laboratory tests were compared before and after MSCT. Results: The eleven patients were followed up for one to thirteen months after MSCT. All patients have not developed transplantation related complications. The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score decreased from 士 to 士 one month after MSCT(n=9, p<. Urine protein co ncentration decreased from 士 mg/24h to 士 mg/24h one month after MSCT (p<, n=10). Five patients that were followed up for six months, the urine protein concentration decreased significantly 士 mg/24h vs. 士24h, n=5, p<. Five patients with hypoproteinemia, the serum albumin increased gradually. One month after MSCT g/L vs. , n=5, p=,two months after MSCT ( g/L vs. , n=2), four months after MSCT g vs. , n=2), eight months after MSCT g vs. , n=2). Complement C3 increased from g/L to g/L(n=9, p< one month after MSCT. The ant-nuclear antibody (ANA) and anti-dsDNA antibody titer decreased after MSCT. In two patients with chronic renal failure, the serum creatinine fell down mildly. Conclusion: Treating refractor