干细胞向胰岛样细胞诱导分化的研究进展.pdf

第 18 卷第 1 期生命科学 Vol. 18, No. 1
2006 年 2 月 Chinese Bulletin of Life Sciences Feb., 2006
文章编号: 1004-0374(2006)01-0075-05
干细胞向胰岛样细胞诱导分化的研究进展
陆琰,张洹*
(暨南大学医学院血液病研究所, 广州 510632)
摘要:目前,糖尿病患病率呈现上升趋势,它已成为严重危害人类健康的疾病之一。胰岛细胞移
植可以用来治疗 1 型和部分 2 型糖尿病,但由于供体细胞来源匮乏,寻找新的细胞来源成了当务之急。
近年来,随着细胞移植和组织工程的日益发展,干细胞研究为新型胰岛的来源开辟了新的途径。本文
综述了近年来干细胞分化为胰岛样细胞的研究进展、存在问题和可能的解决途径。
关键词:干细胞;糖尿病;细胞治疗
中图分类号:Q813; 文献标识码:A
Research progress of differentiation of stem cells into islet-like cells
LU Yan, ZHANG Yuan*
(Insititute of Hematology, Jinan University, Guangzhou 510632, China)
Abstract: The morbidity rate of diabetes mellitus is increasing at present, which is a serious disease damaging
human being’s health. The transplantation of pancreatic islet cells has been used to treat the diabetes type 1 and
2. However, it is necessary to search new sources of insulin-secreting cells for cell therapy of diabetes mellitus
due to lacking of sufficient donor cells. With the development of cell therapy and tissue engineering in recent
years, the new way of new islet cells from stem cells has be found, which can provide new islets for curing of
diabetes. The progress of differentiation from stem cells into islet-like cells, problems and prospect will be
discussed in the review.
Key words: stem cell; diabetes mellitus; cell therapy
1 前言异体胰岛移植成功率低,到 1995 年为止,仅有 8%
近几十年来,糖尿病(dia