盐酸环丙沙星泡腾片.doc

盐酸环丙沙星泡腾片
摘要目的:制备盐酸环丙沙星***泡腾片并建立该制剂的质量控制标准。方法:采用正交设计对处方辅料进行筛选,考察制剂的稳定性及体外释药性能,以紫外分光光度法测定盐酸环丙沙星的含量。结果:制备工艺可行,制剂体外释药性能优于普通片剂、栓剂,对光、热稳定,对湿度不稳定。结论:该制剂为一新型局部外用制剂,质量控制方法准确可靠。关键词盐酸环丙沙星;***泡腾片;质量控制
中图分类号: 文献标识码:A
文章编号:1001-5213(2000)04-0205-03
Preparation and quality control of ciprofloxacin
hydrochloride vaginal effervescent tablet
Liu Hui,Yang Ginxiang,Tang Ren
(Wuhan General Hospital of mand PLA,Hubei Wuhan
430070)
ABSTRACT OBJECTIVE:To prepare ciprofloxacin hydrochloride vaginal effervescent tablets and establish quality control
:The formulational excipients were selected by means of orthogonal design method. Both the stability and the drug release property of the effervescent tablet were
spectrophotometric method for determination of this preparation was :The preparing method was drug release
property of this preparation was better than general tablet and preparation was stable to light and heat,but was unstable to :ciprofloxacin hydrochloride is a new preparation for topical use.
KEY WORDS ciprofloxacin hydrochloride;vaginal effervescent tablet;quality control
盐酸环丙沙星(ciprofloxacin hydrochloride)是第三代喹诺***类广谱抗菌药,对由绿脓杆菌、革兰阳性菌和阴性菌等引起的妇科感染疗效显著[1]。现有环丙沙星片剂和注射剂可供使用。为了增强其局部治疗效果,根据环丙沙星的药理作用特点,制备CIP*HCL***泡腾片,使药物在***内经由片剂泡腾崩解后,均匀持久的分布于***内壁和宫颈粘膜,增加药物与组织的接触面积,产生良好的***局部治疗