丙种球蛋白治疗特发性血小板减少性紫癜疗效观察.doc

丙种球蛋白治疗特发性血小板减少性紫癜疗效观察
【摘要】目的:观察丙种球蛋白治疗血小板减少性紫癜的疗效。方法:将血小板减少性紫癜随机分为2组,治疗组和对照组各15例,对照组给予大剂量维生素C、激素治疗并积极预防及控制感染,治疗组在对照组治疗基础上加用静脉丙种球蛋白1 g/(kg·d),连用5 d;激素总疗程为4~6周。结果:%%,两组比较差异有统计学意义(P<);血小板回升正常时间和停止出血的时间,治疗组及对照组比较差异均有统计学意义(P<)。结论:静脉注射用丙种球蛋白治疗特发性血小板减少性紫癜有较好的疗效。
【关键词】丙种球蛋白;特发性血小板减少性紫癜;儿童
[ABSTRACT] Objective: To observe effect of gamma globulin on idiopathic thrombocytopenic purpura. Methods: Randomly divided patients with idiopathic thrombocytopenic purpura into two groups: observation group and control group with 15 cases per group. Treated control group with vitamin C and hormone at high dosage, while treated observation group with intravenous injection of gamma globulin at 1 g/(kg·d) for 5 days besides antiinfection treatment. The course of hormone was 4~6 : Total efficiency of observation group was %, and % in control group, with significant difference (P<). There was significant difference in the time when platele
t e normal and hemostasis time (P<). Conclusion: Intravenous injection of gamma globulin has satisfactory effect on idiopathic thrombocytopenic purpura.

[KEY WORDS] Gamma globulin; Idiopathic thrombocytopenic purpura; Children
特发性血小板减少性紫癜是一种以血小板计数减少和皮肤与黏膜出血为特征的自体免疫性疾病。糖皮质激素为治疗首选药物,但对严重出血或血小板小于15×109/L者,糖皮质激素显效较慢,而静脉用丙种球蛋白升高血小板的峰值较高,但持续时间短[1]。我们对2008年~2009年收治的30例ITP患儿采取静脉用丙种球蛋白治疗特发性血