2-(2,6-二甲基苯胺基)-2-氧代乙酸促进的铜催化的芳基溴代物的羟基化有机化学.pdf.pdf

有机化学Chinese Journal anic ChemistryARTICLE * E-mail: ******@. &yehao7171@ Received June 1, 2012; revised June 15, 2012; published online June 20, 2012. Project supported by the National Natural Science Foundation of China (No. 20921091). 国家自然科学基金() http://sioc-/ ? 2012 Chinese Chemical Society & SIOC, CASChin. J. Org. Chem. 2012, 32, 1434~1438DOI: -(2,6-二甲基苯胺基)-2-氧代乙酸促进的铜催化的芳基溴代物的羟基化刘向前a张慧*,a蒋咏文*,b(a上海大学化学系上海 200444) (b中国科学院上海有机化学研究所生命有机国家重点实验室上海 200032)摘要 CuI/2-(2,6-二甲基苯胺基)-2-氧代乙酸作为一个高效的催化体系被成功用于芳基溴代物的羟基化反应. 在此催化体系下, 催化剂用量降至2 mol%, 可用于合成各类取代苯酚. 通过调整反应条件, 该催化体系还可用于促进芳香溴代物一锅法合成对称的芳香醚. 关键词铜; Ullmann反应; 2-(2,6-二甲基苯胺基)-2-氧代乙酸; 羟基化; 酚2-(2,6-Dimethylphenylamino)-2-oxoacetic Acid as an Efficient Prompter for the Copper-Catalyzed Hydroxylation of Aryl Bromides Liu, Xiangqian a Zhang, Hui*,a Jiang, Yongwen*,b (a Department of Chemistry, Shanghai University, Shanghai 200444) (b State Key Laboratory of anic and Natural Products Chemistry, Shanghai Institute anic Chemistry,Chinese Academy of Sciences, Shanghai 200032)Abstract CuI/2-(2,6-dimethylphenylamino)-2-oxoacetic acid (DMPAO) as an efficient bination was used forthe hydroxylation of aryl bromides. The catalyst loading is low to 2 mol% and substituted phenols could be prepared in wide assembly. In addition, by modifying the mixed solvent a