4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征有机化学.pdf.pdf

2005年第25卷有机化学Vol. 25, 2005第9期, 1057~1061 Chinese Journal anic Chemistry No. 9, 1057~1061 * E-mail: ******@nk. Received August 16, 2004; revised November 11, 2004; accepted March 23, 2005. 国家973项目(绿色化学农药先导结构及作用靶标的发现与研究, No. 2003CB114406)和天津市科委(超高效磺酰脲除草剂作用机制及农药分子设计研究, No. 033803411)资助项目.·研究论文·4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征李鹏飞王宝雷马宁王素华李正名*(南开大学元素有机化学研究所元素有机化学国家重点实验室天津 300071) 摘要以取代的苯磺酰肼与(取代嘧啶-2-基)-氨基甲酸苯酯在非亲核性碱存在下合成了12个4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物5和3个5与碱形成的有机盐5as, 5bs和5cs. 所有合成化合物均经过元素分析和1H NMR的结构确证. 1H NMR数据证明, 在5as~5cs中, 磺酰氨基脲起到提供质子的作用. 关键词磺酰氨基脲; 合成; 有机盐Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides LI, Peng-Fei WANG, Bao-Lei MA, Ning WANG, Su-Hua LI, Zheng-Ming*(State Key Laboratory of anic Chemistry, Institute of anic Chemistry, Nankai University, Tianjin 300071)Abstract Nucleophilic reaction of phenyl (substituted pyrimidin-2-yl)-carbamate with benzenesulfonyl hydrazine in the presence of DBU or DABCO afforded the pounds 4-(substituted pyrimidin-2-yl)-1- (substituted benzenesulfonyl)semicarbazides 5. anic salts 5as~5cs formed from 5 and DBU or DABCO were also obtained. Structures of 5 and their salts were determined by elemental analysis and 1H NMR spectra. The characteristic chemical shifts of 1H NMR of such salts were sulfonyl semicarbazide; synthesis; organic salt具